Oral Melanotic Macule: Symptoms and Treatment Skinsight Clinical Challenge: Dark Lesion on Lower Lip MPR Figure 7 from Pigmented lesions of the oral mucosa and perioral tissues: a flow chart for the diagnosis and some recommendations for the management. Semantic Scholar Labial lentigines, also called labial melanotic macules, is a benign skin condition that is more common in individuals with darker skin. They most often appear during adulthood although they can develop at