Acetylcysteine for Acetaminophen Poisoning New England Journal of Medicine Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Sex differences in glutathione metabolism and acetaminophen toxicity Ferroptosis and intrinsic drug induced liver injury by acetaminophen and other drugs: a critical evaluation and historical perspective EurekAlert!