Labial melanotic macule Frontiers Mucosal Melanoma: Pathological Evolution, Pathway Dependency and Targeted Therapy Melanotic macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight in single basal melanocytes; NO nests. More info like this in Figure 1 from Dermoscopy of venous lake on the lips: A comparative study with labial melanotic macule Semantic Scholar
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